The No.2 High School of East China Normal University was founded in 1958 and was designated as a key middle school directly under the Shanghai Education Bureau in 1963. In 1978, it was identified as the only key high school directly under the Ministry of Education in Shanghai and a member unit of the UNESCO "Asian Educational Innovation for Development Service Program Contact Center" (APEID). In 2002, the whole school was moved to Pudong Zhangjiang Hi-Tech Park. In April 2020, East China Normal University and the Putuo Government signed a cooperation agreement to collaborate the Putuo Campus of The No.2 High School of East China Normal University (hereinafter referred to as “Putuo Campus”). In September of the same year, Putuo Campus officially enrolled students.

The Putuo Campus is temporarily located in the core area of Putuo District, at No. 1189 Tongchuan Road, boasting convenient transportation with the direct access to Metro Line 15. The campus, filled with the fragrance of books and covered by shades of trees, boasts reasonable layout with the elegant architectural style and the delicate red walls and white windows. The design of the campus puts emphasis on humanistic care, and creates a pleasant learning, working and living environment for teachers and students.

Putuo Campus, like the other three campuses of The No.2 High School of East China Normal University, is an indispensable member of the extended family. The school follows the concept and tradition of "Excellence Education" in The No.2 High School of East China Normal University, shares the integrated management team and identical education model, and enjoys the synchronized teaching agenda and high-quality resources. Meanwhile, the school utilizes the university’s resources to give full play to its advantage of education research and discipline development teaching, and therefore instructs the school-featured curriculum design, teaching and research practice, teacher training and school culture development.